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By admin • 5 April, 2017 • Comments Off on The Effects of Some Selected Antibiotics on GIT Microflora
Table 1b. The Effects of Some Selected Antibiotics on GIT Microflora
Agent | Impact on | Overgrowth of resistant strains | Days to normalization of flora (post- administration) | Other | ||
Entero- bacteria | Entero- cocci | Anaerobic bacteria | ||||
Cefoperazone | ¯¯ | ¯¯ | ¯ | + | not stated | in Lactobacilli and Bifidus; in
C. difficile and Candida; 70% of drug excreted in bile29,48,49 |
Cefotaxime | ¯ | ¯ | – | – | not stated29 | |
Cefotetan | ¯ | | ¯ | + | not stated | in Lactobacilli;
in C. difficile29 |
Cefotiam | ¯ | – | – | + | not stated | in Candida and Pseudomonas; Ñ in Lactobacilli29 |
Cefoxitin | ¯ | | ¯ | + | not stated | in Lactobacilli and Bifidus; in
C. difficile and Candida29,48 |
Ceftazadime | ¯ | – | – | – | not stated | in Lactobacilli29 |
Ceftizoxime | ¯ | – | – | + | not stated | No effect on Lactobacilli; in Citrobacter spp. and Proteus spp.29 |
Ceftriaxone | ¯¯ | ¯¯ | ¯ | + | 28 | in Bifidus; in Candida; 30% of drug excreted in bile29,49 |
Cephradine | – | – | – | – | not stated | No in yeast29 |
Cephrocile | | ¯ | – | + | 4 | in C. difficile29 |
An overview of some of the research investigating the effects of selected antibiotics on the GIT microflora. ¯¯ = strong suppression (> 4 log 10 CFU/g feces); ¯ = mild to moderate suppression (2-4 log 10 CFU/g feces); = increase in number of organisms during therapy; – = no significant change; Ñ= decrease; + = positive result; Bifidus= Bifidobacterium spp.
Table 1c. The Effects of Some Selected Antibiotics on GIT Microflora
Agent | Impact on | Overgrowth of resistant strains | Days to normalization of flora (post- administration) | Other | ||
Entero- bacteria | Entero- cocci | Anaerobic bacteria | ||||
Ciprofloxacin | ¯¯ | ¯¯ | ¯ | – | 7 | in yeast colonization; no effect on Bifidus or Clostridia29,50 |
Clindamycin | – | | ¯¯ | + | 14 | 10% of drug excreted in bile;
production of SCFAs; in Bifidus and Lactobacilli29,36,48,49 |
Doxycycline | ¯ | ¯ | – | + | not stated | No effect on SCFA
production29,36 |
Enoxacin | ¯¯ | – | – | – | 14 | in Candida29 |
Erythromycin | ¯ | ¯ | ¯ | + | not stated | No significant change in Lactobacilli or Bifidus; in yeast colonization;
production of SCFAs29,36,48 |
Imipenem/ cilastatin | ¯¯ | ¯¯ | ¯¯ | – | 14 | in Lactobacilli and Bifidus29 |
Lomefloxacin | ¯¯ | – | – | – | 2129 | |
Metronidazole | – | – | – | – | not stated | No significant change in Lactobacilli, yeasts, Bifidus, or SCFA
production29,36,48 |
Moxalactam | ¯¯ | | ¯¯ | + | 14 | in Lactobacilli and Bifidus; in Candida and
C. difficile29,48 |
Norfloxacin | ¯¯ | – | – | – | 1429 | |
Ofloxacin | ¯¯ | ¯ | – | – | in Lactobacilli and Bifidus; in Candida29 |
An overview of some of the research investigating the effects of selected antibiotics on the GIT microflora. ¯¯ = strong suppression (> 4 log 10 CFU/g feces); ¯ = mild to moderate suppression (2-4 log 10 CFU/g feces); = increase in number of organisms during therapy; – = no significant change; Ñ= decrease; + = positive result; Bifidus= Bifidobacterium spp.
Table 1d. The Effects of Some Selected Antibiotics on GIT Microflora
|
An overview of some of the research investigating the effects of selected antibiotics on the GIT microflora. ¯¯ = strong suppression (> 4 log 10 CFU/g feces); ¯ = mild to moderate suppression (2-4 log 10 CFU/g feces); = increase in number of organisms during therapy; – = no significant change; Ñ= decrease; + = positive result; Bifidus= Bifidobacterium spp.
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